Archive 1992–2014

Contribution of genetic factors toetiopathogenesis of schizophrenia is well documented.Susceptibility to the disease is probably due toan epistatic interaction ofmany genes. This associationstudy was conducted to investigatefrequenciesof alleles and genotypes of the so-called candidategenes in a group of patients with schizophrenia(n=129), and in healthy controls (n=111). Thepaper presents results of association studies on polymorphisms of candidate genes: DRD2 (T/G substitutionin intron 6, at the position -72 from the 5' endof exon 7, and C/T substitution in codon 313 in exon7) and DRD3 (Ball polymorphism in codon 9 of thefirst exon) in schizophrenia. No relationship betweenthe polymorphisms under study and schizophreniahas been confirmed.