Archive 1992–2014

Objective. To present the state-of-the-art research into hereditary factors in the development ofposttraumatic stress disorder (PTSD).

Review. The research on the role ofgenetic factors in PTSD onset was initiated by an observation that children ofparents with PTSD run a higher risk of developing this disorder. Research into PTSD inheritability included familial and twin studies, as well as candidate gene studies. An analysis of PTSD co-morbidity with other genetically determined mental disorders contributes to the explanation of the risk for developing PTSD. Liability for PTSD is associated with a particularly low tolerance to stress and an increased risk of exposure to traumatic events, determined by many factors.

Conclusions. The findings obtained so far in studies on genetic factors underlying PTSD development evidence the need for further research in this area.